Glandokort®
Biologically active food supplement GLANDOKORT® contains a complex of low molecular weight
peptides with a molecular weight of up to 5000 Da, extracted from adrenal tissues of young animals
- calves notolder than 12 months of age or pigs.
GLANDOKORT® is available in capsules with an active substance content of 10 mg.
Experimental studies have shown that peptides have a tissue-specific effect on the cells of those
tissues from which they are isolated. GLANDOKORT® peptides regulate metabolic processes in the
adrenal cortex cells, increase their reserve capacity, and have a beneficial effect on the adaptation
processes of the body in extreme conditions. They also possess antioxidant properties and regulate the
peroxidation processes in the tissues of the adrenal glands. This allows us to assume the effectiveness
of GLANDOKORT® for restoring the functions of the endocrine system in case of their disorders of
various origins, including with prolonged exposure to stress factors, with aging.
Age-related or stress-induced decrease in the functional activity of the adrenal glands is one of the
causes of dyshormonal and maladaptive disorders (3, 4).
Drug treatment of these diseases and pathological conditions includes the use of the following drugs
(1, 2):
- Glucocorticoids - prednisolone, hydrocortisone;
- Mineralocorticoids;
- Adaptogens (ginseng, extracts of Eleutherococcus, Leuzea, Rhodiola rosea, tinctures of aralia, zamanihi,
saparal, pantocrine).
CLINICAL CHARACTERISTICS OF PATIENTS
A clinical study of the effectiveness of the use of GLANDOKORT® was carried out at the Medical
Center of the St. Petersburg Institute of Bioregulation and Gerontology in the period from April to
November 2011.
The study involved 36 patients aged 37 to 62 years, including 25 men and 11 women, with chronic
adrenal cortex insufficiency and conditions after prolonged exposure to occupational and psycho-
emotional stress. Patients of the primary group received complex treatment using adaptogens
(conventional medicine) and GLANDOKORT® 1 capsule 2 times a day with meals for 30 days.
The control groups consisted of 26 patients with similar diseases who were prescribed conventional
treatment with adaptogens. Patients receiving hormone therapy were excluded from the study.
Patients suffering from a chronic adrenal cortex insufficiency or under occupational or psycho-
emotional stress for a long time complained of general weakness, decreased appetite, headaches,
sleep disturbances, increased irritability, and apathy.
RESEARCH METHODS
The effectiveness of GLANDOKORT® was assessed subjectively by studying the dynamics of patients’
complaints and objective indicators. A biochemical blood test was carried out for a general clinical study
of blood and urine. The content of hormones (cortisol, insulin) in the blood serum was determined
by radioimmunological methods. Using various biochemical processes, we defined the content of
adrenaline and aldosterone in the blood plasma. The level of excretion of 17-ketosteroids was found
in the urine.
RESEARCH RESULTS
It was found that the use of GLANDOKORT® contributed to the improvement of the general condition
of patients in the studied group. Patients noted increased physical and mental performance, improved
mood, and sleep.
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