Svetinorm®
Biologically active food supplement SVETINORM® is a complex of low molecular weight peptides with
a molecular weight of up to 5000 Da, obtained from the liver of young animals - calves not older than
12 months of age or pigs. The isolated peptides have a tissue-specific effect on liver cells, restoring
metabolism and normalizing their functional activity.
SVETINORM® is available in tablets or capsules containing 10 mg of active peptides.
Clinical trials of SVETINORM® were carried out at the Medical Center of the St. Petersburg Institute
of Bioregulation and Gerontology, SZO RAMS, in patients with chronic hepatitis and cancer after a
course of radiation or radiation chemotherapy in the period from October 2005 to January 2006.
SVETINORM® was taken by patients orally 10-15 minutes before meals, 1-2 capsules 2 times a day
for 10-20 days, depending on the severity of the pathological process.
Chronic hepatitis is considered not an outcome of an acute infectious process but as a form of the
course of the infectious process (2, 3). Currently, there is an increase in the number of patients
with chronic liver lesions, which are prevalent mainly in people of working age. Adverse social and
environmental factors play a significant role in increased morbidity.
In the treatment of patients with chronic hepatitis, taking into account the pathogenetic mechanisms,
mainly the following conventional means are used (1):
- Drugs that improve the exchange of liver cells (hepatoprotectors) - Essentiale, Legalon, Sirepar;
- Stimulants of bile secretion - Liv-52;
- Vitamins of group B (B1, B6, B12), ascorbic acid;
- etc.
CLINICAL CHARACTERISTICS OF PATIENTS
Clinical trials were carried out in 47 patients with chronic hepatitis and cancer after a course of
chemotherapy, including 30 men and 17 women aged 35 to 68 years (Table 1). In addition to
conventional treatments, patients of the primary group received Svetinorm® 2 capsules 2 times a
day before meals for 15-20 days. The duration of the disease ranged from 3 to 10 years.
The control groups consisted of 38 similar patients prescribed only conventional drugs.
Distribution of patients by nosological forms, sex and age. Table 1
Diagnosis Age Male Female Total
Chronic persistent hepatitis 35-56 21 13 34
Condition after a course of chemotherapy in cancer 53-68 9 4 13
patients
Total: 30 17 47
Most patients complained of pain in the right hypochondrium, general weakness, and rapid fatigability.
In 73% of patients, dyspeptic disorders were noted. In 53% of patients, hyperbilirubinemia, an increase
in the level of alanine aminotransferase, an increase in the globulin fraction of blood proteins, mainly
due to the fraction of immunoglobulins M, were noted, which indicates a certain activity of the chronic
inflammatory process.
RESEARCH METHODS
Patients’ complaints were assessed subjectively in dynamics. A general clinical examination of blood
and urine, biochemical and immunological blood tests (determination of immunoglobulins according
to Mancini), and ultrasound examination of the liver were performed.
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