Chelohart®
Biologically active food supplement CHELOHART® contains a complex of low molecular weight pep-
tides with a molecular weight of up to 5000 Da, isolated from the tissues of the heart of young ani-
mals - calves not older than 12 months of age or pigs.
CHELOHART® is available in capsules with an active substance content of 10 mg.
CHELOHART®’s peptides regulate metabolic processes in myocardial cells, increase the reserve ca-
pacity of myocardiocytes, have a beneficial effect on the adaptation processes of the body in extreme
conditions, and have antioxidant properties, regulating the processes of peroxidation in the myocardi-
um. Experimental studies have shown that peptides have a tissue-specific effect on the cells of those
tissues from which they are isolated. This allows us to assume the effectiveness of using CHELOHART®
to restore the functions of the heart in case of disorders of various origins.
Disorders of myocardial metabolism associated with oxygen deficiency underlie the development of
various forms of ischemic heart disease, is a common link in the pathogenesis of cardiomyopathies and
causes various cardiac disorders. The pathological process is based on a violation of the correspondence
between the heart’s need for blood supply and the functioning of the vascular system. Insufficient
blood supply to the myocardium is most often caused by atherosclerosis of the coronary vessels, one
of the most common age-related pathologies (1). Of particular concern to clinicians in recent decades
is the emergence of this age-related pathology in people of an increasingly young age, which leads to
the «rejuvenation» of myocardial infarction and an increase in the risk of developing its complications.
Ischemic heart disease is one of the most common causes of disability of patients and mortality among
the population of developed countries.
In the conservative treatment of patients with coronary heart disease, taking into account the patho-
genetic mechanisms, the following traditional therapeutic agents of various directions of action are
mainly used (1, 2):
- Vasodilators (nitroglycerin, nitrong, erinit);
- Calcium antagonists (verapamil, fenigidin);
- β-blockers (anaprilin, trazikor);
- Drugs that weaken adrenergic effects on the heart (cordaron);
- etc.
CLINICAL CHARACTERISTICS OF PATIENTS
A clinical study of the effectiveness of using CHELOHART® was carried out at the Medical Center of
the St. Petersburg Institute of Bioregulation and Gerontology from May to November 2011.
The clinical study involved 32 patients with ischemic heart disease - exertional angina of functional
class I and II - aged 46 to 72 years, including 18 men and 14 women. Disease duration ranged from
2 to 9 years.
Patients complained of rapid fatigability, decreased performance, weakness, tinnitus, dizziness, palpita-
tions, shortness of breath, recurrent pain in the heart, limited physical activity, and the onset of chest
pain attacks with characteristic irradiation to the left shoulder, left arm, and interscapular space. 19
patients (59.4%) diagnosed with exertional angina pectoris of the Ist class noted the development of
seizures only with great physical activity; the attacks were quickly stopped after the use of nitroglyc-
erin. In 10 patients (31.2%) diagnosed with exertional angina pectoris of the IInd class, pain attacks
behind the sternum occurred when walking at a distance of more than 500 m and climbing stairs. At
the same time, the patients noted a gradual increase in the frequency of attacks, which required an
increase in the dose of nitro drugs.
On the electrocardiogram, an objective examination in 26 patients (81.2%) revealed signs of impaired
coronary circulation during stress tests: a decrease in the S-T segment, a smoothed or negative T wave
in the standard and corresponding chest areas.
Analysis of the general clinical and biochemical blood tests did not reveal significant deviations from
normal values in each age group.
The patients were divided into 2 groups. The primary group included 22 patients, including 14 men
aged 46 to 64 years old and 8 women aged 51 to 72 years old, who, in addition to conventional meth-
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